MetabolicModerate evidence
Berberine (HCl, dihydroberberine)
Plant alkaloid with metabolic effects — lowers fasting glucose and LDL in multiple meta-analyses. Drug interactions exist.
Goals
MetabolicCardiovascularLongevity (broad)
Timing
With food
Price tier
Medium
Dosage
500 mg, 2–3x daily with meals. Dihydroberberine is 5x more bioavailable than HCl.
Considerations
Interacts with many medications (CYP inhibitor). Consult a doctor before use if you take medications.
Form
Capsule
Scientific detail
AMPK-AktivierungGlukose-ModulationLipidsenkung
Deregulated nutrient sensingChronic inflammation
Evidence base
Studies on Berberine (HCl, dihydroberberine)
My pick
Currently in my stack:
WeightWorld Berberin 500 mg, 120 Kapseln
Before carb-heavy meals for glucose control.