EssentialStrong evidence
Vitamin D3 + K2
Vitamin D status is widely insufficient from autumn through spring in temperate climates. K2 complements D3 synergistically.
Goals
Longevity (broad)CardiovascularImmune
Timing
With food
Price tier
Low
Dosage
1,000–4,000 IU D3/day, dosed to blood level (25-OH-D3 target 40–60 ng/mL). 100–200 µg MK-7 K2.
Considerations
Take with a fatty meal. Test serum levels twice yearly.
Form
CapsuleSublingualLiquid
Scientific detail
Calcium-HomöostaseImmun-ModulationGenregulation
Chronic inflammationAltered intercellular communication
Evidence base