metabolicModerate evidence
Berberine (HCl, dihydroberberine)
Plant alkaloid with metabolic effects — lowers fasting glucose and LDL in multiple meta-analyses. Drug interactions exist.
Dosage
500 mg, 2–3x daily with meals. Dihydroberberine is 5x more bioavailable than HCl.
Considerations
Interacts with many medications (CYP inhibitor). Consult a doctor before use if you take medications.
Where to buy
Affiliate link — we may earn a commission at no extra cost to you.