Evidence base

Studies on NMN (Nicotinamide Mononucleotide)

Auto-loaded from PubMed — grouped by outcome. Each entry links to the original source.

1,452 studies total·Last updated: May 27, 2026Open on PubMed

Energy & endurance · 120

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  1. 01
    An integrated anti-aging framework targeting NAD(+) homeostasis, mitochondrial quality control, and redox stability: Roles of NMN/NR, PQQ, and EGT
    Sun Y, Han JC, Tran K et al. · Redox Biol · 2026
  2. 02
    β-Nicotinamide mononucleotide prevents senescence and lipid accumulation in hepatic stellate cells by restoring SIRT1 function
    Saka T, Hayashi R, Yoshino Y et al. · Chem Biol Interact · 2026
  3. 03
    Circadian rhythm disruption impairs ovarian follicular development via NAD(+) metabolic reprogramming
    Ying YY, Chen X, Yao SY et al. · EBioMedicine · 2026
  4. 04
    Energy-replenishing, mitochondria-targeted hydrogel microspheres mitigate sarcopenia via cellular senescence amelioration
    Bao W, Liu S, Du C et al. · J Control Release · 2026
  5. 05
    Aging Triggers an Intestinal Energy Crisis and HDL3 Deficiency Disrupting Gut-Liver Axis Homeostasis
    Li Y, Bao T, Gao L et al. · Aging Cell · 2026
  6. 06
    The presence of microplastics in human semen and the protective role of nicotinamide mononucleotide against polystyrene nanoplastics-induced reproductive and early embryonic toxicity
    Ren F, Pei J, Li L et al. · J Hazard Mater · 2026
  7. 07
    Reduced Versus Oxidized NAD(+) Precursors Drive Distinct Transcriptomic, Proteomic, and Metabolic Profiles in Hepatocytes
    Vinten KT, Schomakers BV, Denis S et al. · FASEB J · 2026
  8. 08
    NMNAT3 deficiency: a novel red blood cell enzymopathy causing hemolysis by altering NAD levels and glycolysis
    Ruiter TJJ, van Oirschot BA, Waanders E et al. · Blood · 2025
  9. 09
    FOXO1-NMNAT3 axis dysregulation promotes doxorubicin cardiotoxicity: NAD(+) replenishment as a redox-targeted antioxidant therapy
    Cheng F, Zhao M, Wang Q et al. · Redox Rep · 2025
  10. 10
    Effects of Nicotinamide Mononucleotide Supplementation and Aerobic Exercise on Metabolic Health and Physical Performance in Aged Mice
    Hsu YJ, Lee MC, Fan HY et al. · Nutrients · 2025
  11. 11
    Sodium dehydroacetate induces porcine oocyte toxicity by inhibiting TCA cycle activity and mitochondrial function, with nicotinamide mononucleotide as a potential protective agent
    Li N, Li Y, Huang G et al. · Food Chem Toxicol · 2025
  12. 12
    Mitochondrial metabolism reprogramming-mediated cardiomyocyte senescence involved in arsenic stress-evoked heart failure
    Wāng Y, Han Y, Xu DX · Environ Int · 2025
  13. 13
    Nicotinamide mononucleotide ameliorates impaired testicular spermatogenesis in uranium-exposed mice by modulating glycolytic pathways
    Wu H, Huang B, Zhou Z et al. · Toxicol Sci · 2025
  14. 14
    Establishing a novel pathway for the biosynthesis of nicotinamide mononucleotide
    Feng R, Yan Z, Wei G et al. · Enzyme Microb Technol · 2025
  15. 15
    Enhancing nicotinamide mononucleotide production in Escherichia coli through systematic metabolic engineering
    Zhang Z, Liu J, Wang M et al. · J Biotechnol · 2025
  16. 16
    The NAMPT enzyme employs a switch that directly senses AMP/ATP and regulates cellular responses to energy stress
    Zu Y, Wu C, Li F et al. · Mol Cell · 2025
  17. 17
    Glycolytic Dysfunction in Granulosa Cells and Its Contribution to Metabolic Dysfunction in Polycystic Ovary Syndrome
    Cao Z, Zhou Q, An J et al. · Drug Des Devel Ther · 2025
  18. 18
    Metabolic reprogramming and machine learning-guided cofactor engineering to boost nicotinamide mononucleotide production in Escherichia coli
    Xiong B, Yang T, Zhang Z et al. · Bioresour Technol · 2025
  19. 19
    Nicotinamide Adenine Dinucleotide Supplementation to Alleviate Heart Failure: A Mitochondrial Dysfunction Perspective
    Yu F, Zhao H, Luo L et al. · Nutrients · 2025
  20. 20
    Effects of Time-Restricted Fasting-Nicotinamide Mononucleotide Combination on Exercise Capacity via Mitochondrial Activation and Gut Microbiota Modulation
    Shi J, Zhuang T, Li W et al. · Nutrients · 2025
  21. 21
    Nicotinamide mononucleotide enhances porcine sperm quality by activating the SIRT3-SOD2/ROS pathway and promoting oxidative phosphorylation
    Zhang H, Qin X, Bojan N et al. · Anim Reprod Sci · 2025
  22. 22
    CD38-mediated metabolic reprogramming promotes the stability and suppressive function of regulatory T cells in tumor
    Sarkar I, Basak D, Ghosh P et al. · Sci Adv · 2025
  23. 23
    Nampt/SIRT2/LDHA pathway-mediated lactate production regulates follicular dysplasia in polycystic ovary syndrome
    Liu K, Wei H, Nong W et al. · Free Radic Biol Med · 2024
  24. 24
    Nicotinamide Mononucleotide Improves Endometrial Homeostasis in a Rat Model of Polycystic Ovary Syndrome by Decreasing Insulin Resistance and Regulating the Glylytic Pathway
    Zhang W, Zhang J, Xue H et al. · Mol Nutr Food Res · 2024
  25. 25
    Shifting redox reaction equilibria on demand using an orthogonal redox cofactor
    Aspacio D, Zhang Y, Cui Y et al. · Nat Chem Biol · 2024

Cognition · 19

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  1. 01
    [Caffeoylquinic acids from Erigeron breviscapus ameliorates cognitive impairment and mitochondrial dysfunction in AD by activating PINK1/Parkin-mediated mitophagy]
    Pu YZ, Chen HF, Wang XY et al. · Zhongguo Zhong Yao Za Zhi · 2025
  2. 02
    Metabolites in aging and aging-relevant diseases: Frailty, sarcopenia and cognitive decline
    Kondoh H, Kameda M · Geriatr Gerontol Int · 2024
  3. 03
    Nicotinamide mononucleotide pretreatment improves long-term isoflurane anesthesia-induced cognitive impairment in mice
    Xu J, Chen X, Liu S et al. · Behav Brain Res · 2024
  4. 04
    The Combination of Citicoline and Nicotinamide Mononucleotide Induces Neurite Outgrowth and Mitigates Vascular Cognitive Impairment via SIRT1/CREB Pathway
    Zhao N, Zhu X, Xie L et al. · Cell Mol Neurobiol · 2023
  5. 05
    Bazi Bushen capsule attenuates cognitive deficits by inhibiting microglia activation and cellular senescence
    Ji C, Wei C, Li M et al. · Pharm Biol · 2022
  6. 06
    Supplementation with NAD(+) and Its Precursors to Prevent Cognitive Decline across Disease Contexts
    Campbell JM · Nutrients · 2022
  7. 07
    The combination of nicotinamide mononucleotide and lycopene prevents cognitive impairment and attenuates oxidative damage in D-galactose induced aging models via Keap1-Nrf2 signaling
    Liu X, Dilxat T, Shi Q et al. · Gene · 2022
  8. 08
    Nicotinamide mononucleotide (NMN) as an anti-aging health product - Promises and safety concerns
    Nadeeshani H, Li J, Ying T et al. · J Adv Res · 2022
  9. 09
    Nicotinamide phosphoribosyltransferase inhibitor ameliorates mouse aging-induced cognitive impairment
    Zeng M, Wei TF, Chen C et al. · J Cereb Blood Flow Metab · 2021
  10. 10
    Nicotinamide Mononucleotide Prevents Cisplatin-Induced Cognitive Impairments
    Yoo KH, Tang JJ, Rashid MA et al. · Cancer Res · 2021
  11. 11
    Nicotinamide mononucleotide administration after sever hypoglycemia improves neuronal survival and cognitive function in rats
    Wang X, Hu X, Zhang L et al. · Brain Res Bull · 2020
  12. 12
    Nicotinamide Mononucleotide Administration Prevents Experimental Diabetes-Induced Cognitive Impairment and Loss of Hippocampal Neurons
    Chandrasekaran K, Choi J, Arvas MI et al. · Int J Mol Sci · 2020
  13. 13
    Nicotinamide Mononucleotide and Melatonin Alleviate Aging-induced Cognitive Impairment via Modulation of Mitochondrial Function and Apoptosis in the Prefrontal Cortex and Hippocampus
    Hosseini L, Farokhi-Sisakht F, Badalzadeh R et al. · Neuroscience · 2019
  14. 14
    Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular aging
    Tarantini S, Yabluchanskiy A, Csipo T et al. · Geroscience · 2019
  15. 15
    Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment
    Kiss T, Balasubramanian P, Valcarcel-Ares MN et al. · Geroscience · 2019
  16. 16
    Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice
    Tarantini S, Valcarcel-Ares MN, Toth P et al. · Redox Biol · 2019
  17. 17
    Acute Axonal Degeneration Drives Development of Cognitive, Motor, and Visual Deficits after Blast-Mediated Traumatic Brain Injury in Mice
    Yin TC, Voorhees JR, Genova RM et al. · eNeuro · 2016
  18. 18
    Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death
    Wang X, Hu X, Yang Y et al. · Brain Res · 2016
  19. 19
    NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies
    Ali YO, Allen HM, Yu L et al. · PLoS Biol · 2016

Longevity & aging · 162

Open on PubMed
  1. 01
    Iridoids from the edible flowers of Rhododendron pachypodum: structural elucidation and healthspan related bioactivities in Caenorhabditis elegans
    Wang Y, Zhang HR, Luan J et al. · Phytochemistry · 2026
  2. 02
    An integrated anti-aging framework targeting NAD(+) homeostasis, mitochondrial quality control, and redox stability: Roles of NMN/NR, PQQ, and EGT
    Sun Y, Han JC, Tran K et al. · Redox Biol · 2026
  3. 03
    β-Nicotinamide mononucleotide prevents senescence and lipid accumulation in hepatic stellate cells by restoring SIRT1 function
    Saka T, Hayashi R, Yoshino Y et al. · Chem Biol Interact · 2026
  4. 04
    DRP1 in reproduction and reproductive aging
    Huang CR, Cheng YH, Chang YC et al. · Biol Reprod · 2026
  5. 05
    Intracellular NAD(+) Depletion Increases Prostanoid Production via p38/COX2 Signalling in FK866-Induced Senescent Human Umbilical Vein Endothelial Cells
    Kitajima N, Nakajo T, Katayoshi T et al. · J Cell Mol Med · 2026
  6. 06
    Nicotinamide Mononucleotide Improves High-Fat Diet-Induced Myocardial Damage of Aging Mice through the Sirt3/PINK1/Parkin Signaling Pathway
    Wen X, Chen YN, Han YC et al. · J Nutr · 2026
  7. 07
    Sirt1-eIF2α axis drives pro-inflammatory macrophage activation through ER stress aggravating liver IRI in aged mice
    Zhou Y, Wu X, Xu X et al. · Biochem Biophys Res Commun · 2026
  8. 08
    SRN-901, a Novel Longevity Drug, Extends Lifespan and Healthspan by Targeting Multiple Aging Pathways
    Weiss B, Miranda DR, Arrazati D et al. · Drug Des Devel Ther · 2026
  9. 09
    Double-Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration
    Yu J, Hou M, Deng Y et al. · Aging Cell · 2026
  10. 10
    NAD⁺ supplementation for anti-aging and wellness: A PRISMA-guided systematic review of preclinical and clinical evidence
    Gallagher C, Emmanuel OO · Ageing Res Rev · 2026SR
  11. 11
    Uranium exposure induces osteopenia via mitochondrial dysfunction-driven senescence in bone marrow mesenchymal stem cells
    Sheng L, Suo Y, Hong S et al. · J Hazard Mater · 2026
  12. 12
    Energy-replenishing, mitochondria-targeted hydrogel microspheres mitigate sarcopenia via cellular senescence amelioration
    Bao W, Liu S, Du C et al. · J Control Release · 2026
  13. 13
    Aging Triggers an Intestinal Energy Crisis and HDL3 Deficiency Disrupting Gut-Liver Axis Homeostasis
    Li Y, Bao T, Gao L et al. · Aging Cell · 2026
  14. 14
    Enhancing retinal cells anti-attenuation under oxidative stress by NMN-loaded gelatin nanoparticles via efficiently intracellular delivery
    Yang TC, Chu PH, Chen HA et al. · Int J Biol Macromol · 2026
  15. 15
    Comparison of anti-aging effect of PQQ (Pyrroloquinoline quinone) and NMN/NR (Nicotinamide mononucleotide /Nicotinamide riboside) - possible combination use
    Ulpathakumbura S, Lu SK, Gunarathne R et al. · Ageing Res Rev · 2026
  16. 16
    Urolithin Α modulates inter-organellar communication via calcium-dependent mitophagy to promote healthy ageing
    Roussos A, Kitopoulou K, Borbolis F et al. · Autophagy · 2025
  17. 17
    The m6A modification-mediated upregulation of ETS2 translation drives arsenic-induced spermatogonial senescence
    Zhang XY, Zhang YH, Liang NN et al. · Free Radic Biol Med · 2025
  18. 18
    Preventive and Protective Effects of Nicotinamide Adenine Dinucleotide Boosters in Aging and Retinal Diseases
    Noreen S, Lim SS, Lee D · Int J Mol Sci · 2025
  19. 19
    Mitochondrial dysfunction-associated cellular senescence is partially involved in bleomycin-induced pulmonary fibrosis in mice
    Yao YX, Lu X, Li Z et al. · Toxicol Appl Pharmacol · 2025
  20. 20
    Effects of Nicotinamide Mononucleotide Supplementation and Aerobic Exercise on Metabolic Health and Physical Performance in Aged Mice
    Hsu YJ, Lee MC, Fan HY et al. · Nutrients · 2025
  21. 21
    Protective effects of nicotinamide mononucleotide on DNA damage and cell death in A549 cells and aging in C. elegans caused by hydrogen peroxide
    He C, Sun X, Xu T et al. · Mutat Res Genet Toxicol Environ Mutagen · 2025
  22. 22
    Interferon-induced senescent CD8(+) T cells reduce anti-PD1 immunotherapy efficacy in early triple-negative breast cancer
    Fu T, Jin X, He M et al. · Sci Transl Med · 2025
  23. 23
    Emerging strategies, applications and challenges of targeting NAD(+) in the clinic
    Zhang J, Wang HL, Lautrup S et al. · Nat Aging · 2025
  24. 24
    Neurometabolomic impacts of wood smoke and protective benefits of anti-aging therapeutics in aged female C57BL/6J mice
    Scieszka D, Hulse J, Gu H et al. · Part Fibre Toxicol · 2025
  25. 25
    Dual-Functional Nanoparticles to Reverse Osteoblast Senescence and Enhance Calcium Supplementation for Alleviating Senile Osteoporosis
    Yu C, Peng Y, Yu T et al. · Adv Healthc Mater · 2025