Evidence base

Studies on Selenium

Auto-loaded from PubMed — grouped by outcome. Each entry links to the original source.

42,201 studies total·Last updated: May 27, 2026Open on PubMed

Immune system · 1,534

Open on PubMed
  1. 01
    Multifunctional selenium nanoplatforms for synergistic ferroptosis inhibition and immune microenvironment remodeling in oral mucositis
    Ouyang Q, Gao R, Li S et al. · Biomaterials · 2026
  2. 02
    Se-methylselenocysteine alleviates sepsis-associated inflammation by upregulating GPX4 to inhibit macrophage ferroptosis
    Feng H, Yang R, Liu Y et al. · Int Immunopharmacol · 2026
  3. 03
    Engineering selenium-loaded NK-bacterial hybrid vesicle activate innate and adaptive immunity for triple-negative breast cancer therapy
    Peng D, Xue Y, Zheng Q et al. · Biomater Adv · 2026
  4. 04
    β-Selenoester-Crosslinked nanocapsules potentiate immunotherapy by imposing divergent fates in cancer cells and macrophages
    Xianyu B, Lu Z, Xu H et al. · Biomaterials · 2026
  5. 05
    Exploring the molecular mechanism of nano-selenium against IHNV in rainbow trout: in vivo and in vitro studies
    Lu J, Liu Z, Quan J et al. · Fish Shellfish Immunol · 2026
  6. 06
    Autoimmunity, diet and autophagy
    Blaise S, Muller S · Autoimmun Rev · 2026
  7. 07
    A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy
    Yu C, Liu Y, Kang K et al. · Adv Sci (Weinh) · 2026
  8. 08
    Arsenite sensitizes to ferroptosis by disrupting selenium metabolism and reducing GPx4 expression
    Takashima H, Makino R, Taguchi H et al. · Toxicology · 2026
  9. 09
    Selenium-albumin corona rinse ameliorates diabetic periodontitis by inhibiting inflammation, anti-bacterial and improving osteogenesis via activating TrxR1/ROS/β-catenin anti-oxidation cascade
    Zou X, Fan X, Xu P et al. · Biomaterials · 2026
  10. 10
    Zinc-selenium synergistic nanoplatform for augmented cancer immunotherapy via trace-elements-mediated immunomodulation
    Liu H, Cao M, Zhou W et al. · Nanoscale Horiz · 2026
  11. 11
    Selenium and Selenoproteins in Neutrophil Functions
    Lee TJ, Prabhu KS · Biol Trace Elem Res · 2026
  12. 12
    Methaneseleninic acid, a circadian-modulating agent, reactivates latent HIV-1 infection without cellular activation or proliferation
    Stern J, Shepherd RA, Kim Y et al. · J Virol · 2026
  13. 13
    Selenium-loaded sustained-release schizophyllan alleviates pancreatic and pulmonary inflammatory damage in type 1 diabetes mellitus by modulating gut microbiota and T cell balance
    Luo J, Pei S, Ai Z et al. · J Nanobiotechnology · 2026
  14. 14
    Selenium nanoparticles with bioorthogonal targeting to boost CAR-cell therapy for colorectal cancer
    Zhou J, Li G, Xu Y et al. · J Nanobiotechnology · 2026
  15. 15
    Ultrasound-Assisted Extraction, Chemical Modification, Structural Characterization, and Activity Studies of Polysaccharides From Corn Silk
    Zhao X, Xiong L, Wen H et al. · Chem Biodivers · 2026
  16. 16
    Evaluation of the protective effects of selenium against iron overload-induced toxicity in rats using a multiple-markers approach
    Ghayth Alzwawy A, Khazri A, Kouki A et al. · Biomarkers · 2026
  17. 17
    Aberrant ceramide accumulation fuels eosinophilic inflammation by promoting eosinophil extracellular trap formation and release in chronic rhinosinusitis with nasal polyps
    Fang P, Wu M, Chen J et al. · J Allergy Clin Immunol · 2026
  18. 18
    Nano-priming with selenium nanoparticles reprograms seed germination, antioxidant defense, and phenylpropanoid metabolism to enhance Fusarium graminearum resistance in maize seedlings
    Dong Q, Huang T, Zhou C et al. · J Adv Res · 2026
  19. 19
    The caprices of a trace element: selenium's considerable effects on Hashimoto's thyroiditis, though few on Graves' disease
    Duntas LH · Eur Thyroid J · 2026
  20. 20
    Nutritional immunology in lifespan
    Fallah M, Naeini F, Fahimzad FS et al. · Exp Gerontol · 2026
  21. 21
    Reprogramming M2b Macrophages via GPX1 Activation by Selenium Nanoparticles Attenuates Lupus Nephritis
    Lv H, Huang G, Li H et al. · Adv Sci (Weinh) · 2026
  22. 22
    Effects of dietary selenium nanoparticles and pennyroyal essential oil on growth performance, immune-biochemical and antioxidant parameters and disease resistance in Nile tilapia, Oreochromis niloticus
    Yousefi M, Adineh H, Hoseini SM et al. · Fish Shellfish Immunol · 2026
  23. 23
    Selenium Myricaria germanica Polysaccharides-based Nanoparticles to Improve Immune Activity
    Chen C, Fan G, Lin Y et al. · Chem Biodivers · 2026
  24. 24
    Selenium nanoparticles efficiently inhibit M1 macrophage polarization by regulating selenoprotein to scavenge ROS in alleviating rheumatoid arthritis
    Zhong X, Yang Y, Jian L et al. · Colloids Surf B Biointerfaces · 2026
  25. 25
    Can antioxidants' supplementation modulate the impact of dietary deoxynivalenol and zearalenone co-contamination on the systemic and mucosal immune response of weaned pigs?
    Lo Verso L, Lessard M, Lauzon K et al. · J Anim Sci · 2026

Hormones · 1,516

Open on PubMed
  1. 01
    Redox modulation contributes to the antidepressant-like and neuroprotective effects of 7-chloro-4-(phenylselanyl)quinoline in an Alzheimer's disease model
    De Oliveira RL, Pinz MP, Voss GT et al. · Redox Rep · 2026
  2. 02
    Exploiting PKM2-PARP1 dependency: Isoselenazolium-olaparib conjugates achieve multimodal PKM2 suppression
    Dimitrijevs P, Makrecka-Kuka M, Zelencova-Gopejenko D et al. · Bioorg Chem · 2026
  3. 03
    2-Phenyl-3-(phenylselanyl)benzofuran attenuates depressive-like behavior and memory deficits induced by subchronic glucocorticoid exposure in female Swiss mice: role of redox and neurochemical mechanisms
    Strelow DN, Paim MP, Rech TDST et al. · Neuropharmacology · 2026
  4. 04
    Neuro-immune, metabolic, and oxidative pathways in depression due to hypothyroidism and Hashimoto's thyroiditis
    Al-Baldawi SQ, Al-Hakeim HK, Khémiri I et al. · J Affect Disord · 2026
  5. 05
    Melatonin-selenium nanoformulation: a promising therapeutic strategy against Ehrlich ascites carcinoma
    Morad HM, Abdel-Aziz AF, Madkour MM · Sci Rep · 2026
  6. 06
    Myoinositol and Selenium (MYSE) Supplementation Is Associated with Favorable Changes in Thyroid Parameters and Migraine Outcomes in Patients with Migraine and Hashimoto's Thyroiditis: A Retrospective Cohort Study
    Di Lorenzo C, Nordio M, Brongo F et al. · Nutrients · 2026
  7. 07
    Melatonin-dobed nano‑selenium treatment of potato plant induces direct resistance against Spodoptera litura and indirectly reshapes volatile mediated biological interactions
    Munawar A, Yao J, El-Ela AA et al. · Pestic Biochem Physiol · 2026
  8. 08
    PEG-Modified Selenium Nanoparticles Dramatically Increases Antibody Binding Sites for Ultrasensitive Point-of-Care Detection of NT-proBNP
    Wang L, Ji J, Zhao Y et al. · Anal Chem · 2026
  9. 09
    Unraveling the Origins of Thyroid Nodules: Inflammation, Hormones, Toxins, and Micronutrient Interactions
    Mazza AD · Horm Metab Res · 2026
  10. 10
    Nano-selenium ameliorates lead oxide nanoparticle-induced reproductive toxicity in japanese quails via restoring gonadal antioxidant activity and normalization of sex hormones
    Eleouny OI, Abo-Samaha MI, Ghoneim HA et al. · Tissue Cell · 2026
  11. 11
    Iodine and selenium intakes and status and thyroid function in midlife women with low bread intakes in New Zealand
    Berger J, Finlayson J, von Hurst PR et al. · Nutr Diet · 2026
  12. 12
    Effects of Methandienone on the ovaries of rabbits in relation to the aromatase gene (CYP19A1) and oxidative markers and the possible protective role of selenium
    Shahooth MA, Abdulrahman Ghazi M, Khamees Abed S et al. · F1000Res · 2026
  13. 13
    rhBNP inhibited ferroptosis in renal ischemia-reperfusion injury through promoting selenium recycling
    Huang M, Wang L, Wang M et al. · Free Radic Biol Med · 2026
  14. 14
    Green synthesized selenium nanoparticles mitigate cyclophosphamide-induced reproductive toxicity in male Wistar rats
    Aiwale BS, Maurya R, Naqvi S · Naunyn Schmiedebergs Arch Pharmacol · 2026
  15. 15
    Betaine supplementation attenuates high-Se induced insulin resistance in C57BL/6 mice
    Wang J, Zhang X, Wang Q et al. · J Nutr Biochem · 2026
  16. 16
    Moderating effect of selenium intake on the association between obesity and sex hormone levels in children and adolescents: NHANES 2013-2016
    Xu S, Maimaititusvn G, Kulaixi M et al. · Asia Pac J Clin Nutr · 2026
  17. 17
    Associations of roxadustat with copper elevation and hypothyroidism in patients on hemodialysis
    Aoki S, Saito T, Yoshida S et al. · Int Urol Nephrol · 2026
  18. 18
    Associations of metal mixtures with insulin resistance and glucose homeostasis in U.S. adults from the NHANES 2011-2018
    Wu Q, Gan R, Chen S et al. · Sci Rep · 2026
  19. 19
    Effects of Maternal Trace Elements Exposure in Early Pregnancy on Maternal Thyroid Hormones and Birth Outcomes
    Wu T, Li T, Zhang C et al. · Biol Trace Elem Res · 2026
  20. 20
    A Rapid Method Based on Colloidal Selenium Nanoparticle to Detect NT-proBNP Antigen in Serum for Monitoring Acute Heart Failure
    Tang C, Xiang H, Zhu J et al. · Int J Nanomedicine · 2025
  21. 21
    Thyroid-Microbiome Allostasis and Mitochondrial Performance: An Integrative Perspective in Exercise Physiology
    Odriozola A, González A, Odriozola I et al. · Nutrients · 2025
  22. 22
    Selenium Attenuates Dexamethasone-Induced Osteoblast Dysfunction and Prevents Femoral Head Osteonecrosis via PI3K/AKT/GSK3β Pathway Activation
    Xuecheng S, Changjun C, Xiaojie M et al. · Orthop Surg · 2025
  23. 23
    A Comprehensive Review of Selenium as a Key Regulator in Thyroid Health
    Bano I, Hassan MF, Kieliszek M · Biol Trace Elem Res · 2025
  24. 24
    Association of serum melatonin with dietary patterns and dietary nutrients in chinese population: a cross-sectional study
    Zhou HJ, Su H, Zhao C et al. · Eur J Nutr · 2025
  25. 25
    Effect of zinc oxide or selenium nanoparticles on body weight, growth related genes and physiology in Baladi goats
    Farag IM, Aboulthana WM, Ali SM et al. · Sci Rep · 2025

Longevity & aging · 516

Open on PubMed
  1. 01
    Immunometabolic control of cytokine production by micronutrients in health, aging, and inflammation
    Ghosh J, Chattopadhyay D · Front Immunol · 2026
  2. 02
    SEMI-1, A Novel Neuronal Selenium-Binding Protein 1 Homolog Without Methanethiol Oxidase Activity, Modulates Stress Resistance, Lifespan, and Thermotaxis in C. elegans
    Gong W, Köhnlein K, Priebs J et al. · Biofactors · 2026
  3. 03
    Reference intervals for serum macro- and microminerals in clinically healthy horses in Northwestern Spain: Influence of age, sex, breed and diet
    Fernández-Villa C, Miranda M, Rigueira L et al. · J Equine Vet Sci · 2026
  4. 04
    Aging, oxidative stress, and cataracts: Therapeutic prospects and translational insights into peroxiredoxin 6
    Kubo E, Chhunchha B, Singh DP · Prog Retin Eye Res · 2026
  5. 05
    Association of the essential metal mixture with biological aging in Chinese older adults: Investigating superoxide dismutase as a potential mediator
    Zhang Y, Tian Z, Wei R et al. · Ecotoxicol Environ Saf · 2026
  6. 06
    Nutritional immunology in lifespan
    Fallah M, Naeini F, Fahimzad FS et al. · Exp Gerontol · 2026
  7. 07
    Mitochondria and Aging: Redox Balance Modulation as a New Approach to the Development of Innovative Geroprotectors (Fundamental and Applied Aspects)
    Mironova E, Kvetnoy I, Balazovskaia S et al. · Int J Mol Sci · 2026
  8. 08
    Effects of Selenium Deficiency and the Environmental Pollutant Trimethylstannyl Chloride on Aging in Broiler Chickens Based on Adverse Outcome Pathways
    Xie R, Liu M, Xu T et al. · J Agric Food Chem · 2026
  9. 09
    Metals exposure, biological aging and metabolic syndrome: exploring the associations and mediation effects
    Han X, Lv Z, He M et al. · J Nutr Biochem · 2026
  10. 10
    Chitosan Nano-Selenium Supplementation Improves Production Performance, Egg Quality, and Selenium Deposition in Aging Laying Hens
    Shu G, Yi X, Yang L et al. · Biol Trace Elem Res · 2026
  11. 11
    Enhanced Selenium Supplement Extends Lifespan and Delays Multi-Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis
    Yu Y, Song J, Guo M et al. · Adv Sci (Weinh) · 2025
  12. 12
    Selenium and brain aging: A comprehensive review with a focus on hippocampal neurogenesis
    Daneshpour A, Leite MEN, Wagner KH et al. · Ageing Res Rev · 2025
  13. 13
    Association of composite dietary antioxidant index with menopause age and reproductive lifespan in NHANES 1999-2018: A Cross-Sectional study
    Zhao X, Huang Z, Shi N et al. · Sci Rep · 2025
  14. 14
    Influence of Dietary Habits on Oxidative Stress Parameters, Selenium, Copper, and Zinc Levels in the Serum of Patients with Age-Related Cataract
    Falkowska M, Zawadzka I, Grabia-Lis M et al. · Nutrients · 2025
  15. 15
    Rapamycin coated selenium nanoparticles relieve oxidative senescence of vascular endothelium by mitophagy
    Zhang Y, Wang J, Yang H et al. · Redox Biol · 2025
  16. 16
    Role of Micronutrient Supplementation in Promoting Cognitive Healthy Aging in Latin America: Evidence-Based Consensus Statement
    Nogueira-de-Almeida CA, Gutiérrez CAC, Ramos LR et al. · Nutrients · 2025
  17. 17
    Dietary Selenium Deficiency Accelerates the Onset of Aging-Related Gut Microbial Changes in Aged Telomere-Humanized Mice, With Akkermansia muciniphila Being the Most Prominent and Alleviating Selenium Deficiency-Induced Type 2 Diabetes
    Huang YC, Lu HY, Zhang L et al. · Aging Cell · 2025
  18. 18
    Cytomegalovirus (CMV), oxidative stress, and inflammation: implications for immunosenescence and age-related diseases in the MARK-AGE population
    Cianfruglia L, Fortunato C, Badillo Pazmay GV et al. · Biogerontology · 2025
  19. 19
    Associations between serum trace elements and biological age acceleration in the Chinese elderly: A community-based study investigating the mediating role of inflammatory markers and the moderating effect of physical activity
    Wang Y, Zhu W, Zhang T et al. · J Hazard Mater · 2025
  20. 20
    Selenium alleviates cadmium-induced biological aging acceleration and the potential mediating role of inflammation
    Li C, Xiang Y, Liu M et al. · Ecotoxicol Environ Saf · 2025
  21. 21
    From soil to the intestinal tract: The key role of beneficial elements and probiotics in promoting health and longevity
    Zhang W, Wu S, Jho EH et al. · J Environ Manage · 2025
  22. 22
    Neuroprotective effects of selenium against lithium-induced cerebellar toxicity in rats: The role of apoptosis, gliosis, and aging markers
    Helal NE, Ali LS, Elsaed WM et al. · Tissue Cell · 2025
  23. 23
    Consumptıon of ultra-processed foods can accelerate age-related appearance of sarcopenıa
    Parlak Baskurt H, Yardımcı H · Biogerontology · 2025
  24. 24
    Low blood levels of selenium, selenoprotein P and GPx3 are associated with accelerated biological aging: results from the Berlin Aging Study II (BASE-II)
    Vetter VM, Demircan K, Homann J et al. · Clin Epigenetics · 2025
  25. 25
    Enhanced Sperm Quality in Aged Broiler Breeder Roosters with Organic Selenium and Selenium Nanoparticles: A Comparative Bioavailability Study
    Asghari-Moghadam M, Mehri M · Biol Trace Elem Res · 2025