Evidence base

Studies on Quercetin (with bromelain)

Auto-loaded from PubMed — grouped by outcome. Each entry links to the original source.

32,011 studies total·Last updated: May 27, 2026Open on PubMed

Longevity & aging · 465

Open on PubMed
  1. 01
    Ceramic-based biomaterials: Combining regeneration with anti-senescence
    Ma X, Yang Z, Jin K et al. · Biomaterials · 2026
  2. 02
    Senolytic therapy ameliorates high-fat diet-induced hippocampal senescence and cognitive decline in mice
    Xia X, Yi F, Zhang R et al. · Exp Neurol · 2026
  3. 03
    Integrative transcriptomics and single-cell analysis unravel the senescence-reversing mechanism of quercetin in osteoarthritic chondrocytes
    Hu Z, Chen Y, Yao Y et al. · Biochem Biophys Res Commun · 2026
  4. 04
    Computational exploration of squalene analog 4,4'diapophytofluene as a potential anti-aging phytotherapeutic
    Dutta M, Hazra A, Mandal Biswas S · Comput Biol Chem · 2026
  5. 05
    Geroprotective effects of bioactive compounds against hydroquinone toxicity in Drosophila melanogaster: an in vivo and in silico insight
    Cherian J, Kunigiri S, Vegesna J et al. · Biogerontology · 2026
  6. 06
    T-Cell Immunosenescence in Systemic Lupus Erythematosus: Molecular Mechanisms and Therapeutic Perspectives
    Zhou S, Jian L, Chen H et al. · Clin Rev Allergy Immunol · 2026
  7. 07
    Lipid- and Polymer-Based Nanoscale Delivery of Anti-Aging Phytochemicals
    Gross S, Vogtlander C, Lewis C et al. · Wiley Interdiscip Rev Nanomed Nanobiotechnol · 2026
  8. 08
    Targeting Hyperoxia-Induced Cellular Senescence in Developing Human Airway Cells: Senomorphics Versus Senolytics Versus Antioxidants
    Koloko Ngassie ML, Drake LY, Zhu Y et al. · Aging Cell · 2026
  9. 09
    Extracellular vesicles derived from senescent hepatocytes drive pan-cancer metastasis in aging
    Li H, Zhao R, Wan L et al. · Nat Aging · 2026
  10. 10
    Quercetin attenuates tendon stem/progenitor cell senescence and promotes aged tendon repair via AKT/NF-κB/NLRP3-mediated mitophagy activation
    Wang H, Gao YC, Ming-Zhang et al. · J Adv Res · 2026
  11. 11
    Dietary Polyphenols in Aging: A Systems-Level Perspective on Mitochondrial Quality Control and Microbiome Interactions
    Yılmaz A, Park HJ, Ahn EM et al. · Int J Mol Sci · 2026
  12. 12
    Senolytics alleviate cyclophosphamide-induced premature ovarian insufficiency by eliminating senescent cells
    Su H, Ma R, Su D et al. · Eur J Histochem · 2026
  13. 13
    Exploring the Senotherapeutic Potential of Polyphenols in Aging and Disease: A Literature Review
    Braučič Mitrovic L, Semen KO · Int J Mol Sci · 2026
  14. 14
    SRN-901, a Novel Longevity Drug, Extends Lifespan and Healthspan by Targeting Multiple Aging Pathways
    Weiss B, Miranda DR, Arrazati D et al. · Drug Des Devel Ther · 2026
  15. 15
    Dasatinib and quercetin senolytic treatment delays early onset intervertebral disc degeneration in SM/J mice
    Novais EJ, Ottone OK, Jagannath S et al. · Bone Res · 2026
  16. 16
    The senescent niche hypothesis: microglial dysfunction and replacement strategies in drug-resistant epilepsy
    Wu J, Li M, Shi Y et al. · Front Immunol · 2026
  17. 17
    FOXP1 deficiency exacerbates cellular senescence in PM(2.5)-induced renal injury
    Chen H, Zhan Z, Lu M et al. · Ecotoxicol Environ Saf · 2026
  18. 18
    PPAR-γ suppresses macrophage senescence and allergic airway inflammation through controlling lipid metabolic pathways
    Gu W, Wan R, Chen Z et al. · EBioMedicine · 2026
  19. 19
    Nanocarriers for lung health: ameliorating inflammation and cell aging using flavonoid-based nano nutrients
    Prasher P, Sharma M, Fatima R et al. · Immunopharmacol Immunotoxicol · 2026
  20. 20
    Identification of key genes modules linking brain aging signatures and COVID-19-associated cognitive impairment
    Xie C, Zhao Y, Wang B et al. · Virus Res · 2026
  21. 21
    Senescent Cell Clearance Ameliorates Temporal Lobe Epilepsy and Associated Spatial Memory Deficits in Mice
    Khan T, McFall DJ, Hussain AI et al. · Ann Neurol · 2026
  22. 22
    Sex-specific proteostasis and urothelial responses to senolytic therapy in the aged mouse bladder
    Kasturi S, Salazar AM, Hardy CC et al. · J Gerontol A Biol Sci Med Sci · 2026
  23. 23
    DHODH inhibition impairs mitochondrial function and extravillous trophoblast invasion: Protective roles of quercetin and riboflavin
    Yoshida K, Kusama K, Kanazawa K et al. · J Pharmacol Sci · 2026
  24. 24
    Targeting senescent cells in aged adipose tissue induced by ovarian cancer with the NF-κB inhibitor quercetin and resveratrol impedes the growth and metastasis of ovarian cancer
    Lv J, Fan Q, Zhe J et al. · Sci China Life Sci · 2026
  25. 25
    Evaluating senescence-targeted approaches in Alzheimer's Disease: What we know and what lies ahead
    Doshi PP, Desale SH, Khutale AA et al. · Ageing Res Rev · 2026

Cardiovascular · 1,012

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  1. 01
    Integrated bioinformatics analysis reveals cross-talking hub genes and therapeutic agents between sepsis and acute myocardial infarction
    Zhou L, Chen W, Li J et al. · Ann Med · 2026
  2. 02
    Uncovering the active substances of Modified Fangjihuangqi Decoction in reducing cardiomyocytes' mitochondrial oxidative damage
    Chen H, Luo Y, Lin S et al. · J Pharm Biomed Anal · 2026
  3. 03
    Elucidating the anti-atherosclerotic mechanism of Huangqi Chifeng Tang via a multi-source data weighted target screening model and experimental validation
    Liang Y, Jiang X, Liu J et al. · Int Immunopharmacol · 2026
  4. 04
    Cardiac targeting extracellular vesicles combined with quercetin co-delivery system enhances the therapeutic efficacy of myocardial infarction
    Zhang X, Wang R, Li X et al. · Biomater Adv · 2026
  5. 05
    Quercetin alleviates atherosclerosis associated with reduced lysophosphatidylcholine-induced macrophage extracellular traps formation and modulation of the JNK/Sp1/PAD4 pathway
    Liang N, Ying L, Huang X et al. · J Nutr Biochem · 2026
  6. 06
    Engineered Liposomal Quercetin Attenuates Myocardial Ischemia/Reperfusion Injury via Targeted HMGB1-NF-κB Suppression
    Meng Y, Tu Q, Han M et al. · Phytomedicine · 2026
  7. 07
    Molecular mechanisms of shenhong tongluo formula against myocardial ischemia-reperfusion injury: Insights from RNA sequencing, bioinformatics, reverse network pharmacology, molecular docking, and molecular dynamics simulations combined with experimental studies
    He R, Liang Z, Liu J et al. · Phytomedicine · 2026
  8. 08
    Healing the heart naturally: The role of bioactive phytocompounds in cardiovascular therapeutics
    Anand A, Srivastava S, Sharma D et al. · Phytomedicine · 2026
  9. 09
    Quercetin Antagonizes Doxorubicin-Induced Cardiotoxicity via HO-1/PGC-1α-ALOX5 Axis: Arachidonic Acid Metabolism-Ferroptosis Crosstalk as a Therapeutic Target
    Duan F, Zeng X, Yi L et al. · Cardiovasc Toxicol · 2026
  10. 10
    Self-Assembled Quercetin-Mecobalamin Nanoparticles Mitigate Ischemic Stroke Injury via Enhanced Neuroprotection and Microglial Modulation
    Zhang T, Fan S, Ji H et al. · ACS Biomater Sci Eng · 2026
  11. 11
    Exploring the mechanism of saffron in treating viral myocarditis using network pharmacology and molecular docking
    Zhu Z, Hu J, Li L · Medicine (Baltimore) · 2026
  12. 12
    UPLC-Q-TOF-MS-Driven Systems Pharmacology Analysis of Dengzhan Shengmai Capsule Against Heart Failure: Integrating Serum/Tissue Distribution, Molecular Docking, and scRNA-seq Evidence
    Li Z, Yang X, Yuan F et al. · Biomed Chromatogr · 2026
  13. 13
    Network pharmacology and machine learning reveal multi-target mechanisms of poly herbal formulation against atherosclerosis
    Shafique M, Umer Ghori M, Hassan M et al. · Pak J Pharm Sci · 2026
  14. 14
    Yigan mingmu decoction treats diabetic retinopathy via Müller cell autophagy: A network pharmacology study
    Wang X, Hu ZY, Hu Q et al. · Phytomedicine · 2026
  15. 15
    Nanoplatform for renal ischemia-reperfusion injury repair: Modulating macrophage polarization, oxidative stress, and mitophagy
    He M, Liu T, Zhao H et al. · Biomater Adv · 2026
  16. 16
    Modulation of Redox Balance by Phytochemicals: Implications for Cardiovascular Health
    Jaganjac M, Orie NN · Nutrients · 2026
  17. 17
    Network pharmacology analysis and experimental validation of modified Taohong Siwu decoction against atherosclerosis
    Shao C, Meng W, Ning K et al. · In Vitro Cell Dev Biol Anim · 2026
  18. 18
    Integrating Network Pharmacology and In Vitro 3D Cardiac Organoid Model Validation to Investigate the Action Mechanism of Shenfu Xiangshao Decoction on Heart Failure
    Yao S, Zhang H, Li M et al. · J Cardiovasc Pharmacol · 2026
  19. 19
    A molecular perspective on cardioprotective potential of Moringa oleifera Lam. and its nano-formulations
    Thanikachalam PV, Mallapu P, Dhalapathy VV et al. · Phytomedicine · 2026
  20. 20
    Bioinformatics approach to identifying molecular targets of Danlou tablet against atherosclerosis: a machine learning pharmacology study
    Wang L, Zhang M, Wang H et al. · Naunyn Schmiedebergs Arch Pharmacol · 2026
  21. 21
    Quercetin targeted NF-κB to regulate platelet activation and prevent arterial thrombosis
    Wang W, Li Y, Liu Y et al. · Tissue Cell · 2026
  22. 22
    Quantum modeling of Stokes-Induced Stark Fields in quercetin-ZnO nanohybrids for bias-free bioelectric repair of chronic diabetic foot ulcers
    Udoisoh M, Ekanem EM, Obiya WO et al. · J Mol Model · 2026
  23. 23
    Quercetin Alleviates Cerebral Ischemia-Induced Neuroinflammation by Inhibiting Microglia-Mediated NLRP3/Caspase-1/GSDMD Pathway
    Shen D, Kong W, Qiu H et al. · Cells · 2026
  24. 24
    Nature's Bioactives in Cardiorenal Syndrome: Polyphenols at the Crossroads-Preclinical Insights into Redox, Inflammation, and Mitochondrial Protection
    Carollo C, Ciuppa ME, Sorce A et al. · Nutrients · 2026
  25. 25
    SIRT-1 activation by quercetin opposes the actions of three transcription factors: p53, ATF4, and NF-κB in a renal ischaemia reperfusion injury in rats
    Elsherbiny MA, Bishr A, Sherif MM et al. · J Pharm Pharmacol · 2026

Immune system · 1,244

Open on PubMed
  1. 01
    Elucidating the protective role of quercetin against lipopolysaccharide-induced necroptosis in broiler thymus: insights from Nrf2/PERK signaling based on network pharmacology and experimental validation
    Xia Y, Xie R, Huo X et al. · Redox Rep · 2026
  2. 02
    Cardiac targeting extracellular vesicles combined with quercetin co-delivery system enhances the therapeutic efficacy of myocardial infarction
    Zhang X, Wang R, Li X et al. · Biomater Adv · 2026
  3. 03
    Structurally diverse clerodane diterpenoids with anti-inflammatory and anti-diabetic effects from Tinospora crispa (L.) Hook.f. & Thomson
    Chen X, Gao T, Wang Q et al. · Phytochemistry · 2026
  4. 04
    Quercetin alleviates atherosclerosis associated with reduced lysophosphatidylcholine-induced macrophage extracellular traps formation and modulation of the JNK/Sp1/PAD4 pathway
    Liang N, Ying L, Huang X et al. · J Nutr Biochem · 2026
  5. 05
    Artificial intelligence and multi-omic empowered-tracing macrophage diagnostic and druggable implications in coronavirus pneumonia
    Li J, Yang D · Comput Biol Chem · 2026
  6. 06
    Integrating bioinformatics, machine learning and molecular biology to elucidate the anti-allergic mechanisms of ginkgo biloba leaves
    Ren Y, Wu M, Liu K et al. · Comput Biol Chem · 2026
  7. 07
    Quercetin-driven M2 polarization of macrophages via ALOX5 inhibition in kupffer cells: A strategy for mouse liver fibrosis treatment
    Chen C, Cui D, Yang S et al. · Gene · 2026
  8. 08
    Quercetin Inhibits Orthodontic Tooth Movement-Associated Periodontitis by Regulating Macrophage Aerobic Glycolysis Through the IL-17/Hippo/YAP Axis
    Yao F, Song Z, Wu W et al. · Clin Exp Dent Res · 2026
  9. 09
    The silymarin and quercetin-loaded pH-sensitive chitosan-tripolyphosphate/Eudragit® S100 nanoparticles improve acetic acid-induced colonic inflammation in rats by modulating Th1 cells, inflammatory cytokines, and oxidative stress
    Bagheri N, Badihi M, Mirzaei Y et al. · Eur J Pharmacol · 2026
  10. 10
    T-Cell Immunosenescence in Systemic Lupus Erythematosus: Molecular Mechanisms and Therapeutic Perspectives
    Zhou S, Jian L, Chen H et al. · Clin Rev Allergy Immunol · 2026
  11. 11
    Spore-inspired surface engineering enhances macrophage phagocytosis for inhalation therapy of acute lung injury
    Kuang X, Jiang Q, Guo Z et al. · J Control Release · 2026
  12. 12
    An Unusual Spiro-Fused Indole Alkaloid-Terrein Hybrid From Marine-Derived Fungus Aspergillus chevalieri HK-56
    Xie W, Nong X, Kuang Y et al. · Chem Biodivers · 2026
  13. 13
    Quercetin alleviates LPS-induced inflammation and immunosuppression in broiler spleen via regulating the mtDNA/cGAS/STING axis
    Bao R, Xu S · Int Immunopharmacol · 2026
  14. 14
    Macrophage Membrane-Cloaked, ROS-Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome
    Li W, Guan Y, Song N et al. · Adv Healthc Mater · 2026
  15. 15
    Nanoplatform for renal ischemia-reperfusion injury repair: Modulating macrophage polarization, oxidative stress, and mitophagy
    He M, Liu T, Zhao H et al. · Biomater Adv · 2026
  16. 16
    Que/n-HA/PGCL microspheres orchestrate bone repair via context-dependent osteoimmune mechanisms: a transcriptomic dissection of direct and immune-mediated signaling
    Han C, Wang Q, Yang S et al. · Front Immunol · 2026
  17. 17
    Brake-Drive Osteo System: Sequential Modulation of the Inflammatory Microenvironment and Osteogenesis for Osteoporotic Bone Defect Regeneration
    Xiao Z, Feng C, Xu C et al. · Adv Mater · 2026
  18. 18
    PPAR-γ suppresses macrophage senescence and allergic airway inflammation through controlling lipid metabolic pathways
    Gu W, Wan R, Chen Z et al. · EBioMedicine · 2026
  19. 19
    Buckwheat Flavonoids Modulate Inflammation in RAW 264.7 Macrophages at Physiologically Relevant Concentrations via the LPS/COX-2 Pathway
    López-Cánovas DJ, Vico-Padilla A, Zielińska D et al. · J Agric Food Chem · 2026
  20. 20
    Chlorogenic acid and quercetin alleviate food allergy responses through the PPAR-γ signaling pathway in mice
    Jiang S, Huang Y, Luo T et al. · J Sci Food Agric · 2026
  21. 21
    ZmWRKY92-Mediated miR169s/NF-YA13 Module Confers Maize Resistance to Bipolaris maydis by Activating Flavonoid Biosynthesis
    Song Z, Ma Z, Wang Y et al. · Mol Plant Pathol · 2026
  22. 22
    High-Resolution MS/MS Characterization of Vine Leaf Flavonols and Flavanonols of Fungal-Resistant Varieties
    De Rosso M, Carraro R, Maoz I et al. · J Mass Spectrom · 2026
  23. 23
    Mechanism of Action of San Ren Decoction in PLWH Treatment Determined Using Network Pharmacology Combined with Experimental Validation
    Wang J, Zhang M, Qicheng J et al. · AIDS Res Hum Retroviruses · 2026
  24. 24
    Bioflavonoid quercetin upregulates biofilm-degrading genes pslG and pelA in Pseudomonas aeruginosa and also alleviates pathogenicity through cytokine modulation in infected macrophages
    Moulick S, Bhattacharya T, Roy DN · Naunyn Schmiedebergs Arch Pharmacol · 2026
  25. 25
    Regulatory role of quercetin, cinnamaldehyde, and glycerol monolaurate complex on lipid metabolism and antiviral mechanisms against white spot syndrome virus in Penaeus vannamei
    Yu X, Chen Z, Li Y et al. · Microb Pathog · 2026