Evidence base

Studies on Berberine (HCl, dihydroberberine)

Auto-loaded from PubMed — grouped by outcome. Each entry links to the original source.

8,063 studies total·Last updated: May 27, 2026Open on PubMed

Metabolic health · 552

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  1. 01
    Dual-targeting strategies for cancer and diabetes: Converging pharmacological pathways and repurposed therapies
    Bhatti GK, Ahmed I, Sehrawat A et al. · Mol Aspects Med · 2026
  2. 02
    Nano-liposomal berberine and vildagliptin combination: A novel therapeutic approach against oxidative stress, inflammation, autophagy dysregulation, and fibrosis in diabetic nephropathy
    Eskandrani AA, Khater SI, El-Emam MMA et al. · Tissue Cell · 2026
  3. 03
    Mechanisms of efficacy of drug therapy in type 2 diabetes: the role of microbiomes
    Li Y, He Z, Li C et al. · Minerva Endocrinol (Torino) · 2026
  4. 04
    Synergistic Potential of Berberine and Metformin: Unlocking Enhanced Anti-Diabetic Efficacy
    Bhushan R, Rehman MT, AlAjmi MF et al. · Chem Biol Drug Des · 2026
  5. 05
    Chitosan-Based Thermosensitive Hydrogel Codelivering Berberine and Resveratrol Promotes Wound Healing of Bacterial Infection in Diabetic Mice
    Chen Z, Yan J, Wang Q et al. · ACS Appl Bio Mater · 2026
  6. 06
    Identification of novel bioactive constituents from traditional decoction of jiao-tai-Wan based on "co-decoction reaction" and comparative analysis with formula granules
    Sun P, Li S, Teng J et al. · J Chromatogr B Analyt Technol Biomed Life Sci · 2026
  7. 07
    Demethyleneberberine attenuates combined cognitive and metabolic dysfunctions in an insulin-resistance-induced Alzheimer's disease rat model: Synthesis, in-silico and in-vivo insights
    Kaur A, Singh S, Singh M et al. · Exp Neurol · 2026
  8. 08
    Gegen Qinlian decoction ameliorates insulin resistance in type 2 diabetes: A systematic review and meta-analysis of RCTs with mechanistic insights into SIRT1/AMPK pathway activation
    Liao Y, Yang L, Tang S et al. · J Ethnopharmacol · 2026SR
  9. 09
    Vanadyl Acetylacetonate and Berberine Synergistically Ameliorate Diabetes-induced Vascular Dysfunction and Reduce Endothelial Toxicity through ERK and Akt Regulation
    Sun J, Shi N, Zhang X et al. · Biol Trace Elem Res · 2026
  10. 10
    Local cochlear delivery of berberine chloride hydrate via an injectable photo-crosslinked hydrogel for treating diabetes- induced hearing loss
    Konduru N, Wang C, Liu S et al. · J Control Release · 2026
  11. 11
    Berberine inhibits ISG15 and pyroptosis to attenuate diabetic kidney disease inflammation and fibrosis
    Huang L, Chen Q, Liu X et al. · Apoptosis · 2026
  12. 12
    Berberine Alleviates Pancreatic β-Cell Ferroptosis and Injury in db/db Mice by Regulating the AGE/RAGE Pathway: Insight from Proteomic Analysis
    Liu XC, Liu YG, Lv YN et al. · Curr Med Sci · 2026
  13. 13
    Comparative Pharmacokinetics and Tissue Distribution of Berberine From Bile-Processed Coptidis Rhizoma in Type 2 Diabetic Rats
    Zhu Y, Yang L, Huang Q et al. · Chem Biodivers · 2026
  14. 14
    Berberine and N-Acetylcysteine ameliorate diabetes-induced hippocampal damage by inhibiting apoptosis and neuroinflammation, and improve synaptic plasticity in rats
    Altındağ F, İgit T · J Mol Histol · 2026
  15. 15
    Jiangtang Tiaozhi formula improves obesity and insulin resistance by inhibiting skeletal muscle inflammation and pyroptosis in diet-induced obese mice
    Qi H, Zhang Z, Hou T et al. · Phytomedicine · 2026
  16. 16
    Glucose-responsive hyaluronic acid/carboxymethyl chitosan-based hydrogel with on-demand berberine release for diabetic wound healing
    Li X, Huang Y, Du Y et al. · Int J Biol Macromol · 2026
  17. 17
    A Hydrogel with Low-Temperature Photothermal Therapy and ROS Scavenging Capability for Healing Infected Diabetic Wound
    Liu X, Liu S, Ma B et al. · Adv Healthc Mater · 2026
  18. 18
    Exploration mechanisms of Coptis chinensis Franch. and Rehmannia glutinosa Libosch. against T2DM based on network pharmacology and molecular docking
    Zhang Y, Zuo H, Zhang C et al. · Medicine (Baltimore) · 2025
  19. 19
    Protective effects of berberine-loaded chitosan/solid lipid nanoparticles in streptozotocin-induced gestational diabetes mellitus rats
    Liu Y, Hussain SA, Yue H · Exp Biol Med (Maywood) · 2025
  20. 20
    Targeting the TLR4 axis with microbiota-oriented interventions and innovations in diabetes therapy: a narrative review
    Nikolaidis CG, Gyriki D, Stavropoulou E et al. · Front Immunol · 2025
  21. 21
    Discovering bioactive pharmaceuticals from natural products for type 2 diabetes mellitus using network pharmacology, molecular docking, and molecular dynamics
    Rahmani B, Akbari H, Esmaeili H et al. · Sci Rep · 2025
  22. 22
    Clinical Efficacy of Curcumin, Resveratrol, Silymarin, and Berberine on Cardio-Metabolic Risk Factors Among Patients With Type 2 Diabetes Mellitus: A Systemic Review and Bayesian Network Meta-Analysis
    Miao R, Zhang B, Zhou D et al. · Phytother Res · 2025SR
  23. 23
    Nrf2-Mediated Ferroptosis Is Involved in Berberine-Induced Alleviation of Diabetic Kidney Disease
    Gao K, Liu Y, Li K et al. · Phytother Res · 2025
  24. 24
    Herbal Approaches to Diabetes Management: Pharmacological Mechanisms and Omics-Driven Discoveries
    Roy D, Ghosh M, Rangra NK · Phytother Res · 2025
  25. 25
    Berberine ameliorates acute hyperglycemia and hypoinsulinemia induced by ketamine/xylazine in rats: role of alpha(2) adrenergic receptors, oxidative stress and inflammatory suppressing mechanisms
    Kadhim RA, Erfanparast A, Tamaddonfard E et al. · BMC Vet Res · 2025

Cardiovascular · 434

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  1. 01
    Targeting lipophagy in atherosclerosis: Molecular mechanisms, pathogenesis and therapeutic interventions (Review)
    Nan S, Peng C, Meng X et al. · Mol Med Rep · 2026
  2. 02
    Healing the heart naturally: The role of bioactive phytocompounds in cardiovascular therapeutics
    Anand A, Srivastava S, Sharma D et al. · Phytomedicine · 2026
  3. 03
    Machine Learning for Cardiovascular Prevention Prescriptions: Real-World vs. Synthetic Data
    Benani A, Grosgeorge D, Bauvin P et al. · Stud Health Technol Inform · 2026
  4. 04
    The complex relationship between cardiologists and lipid-lowering dietary supplements: Hate or love?
    Cicero AFG, Corsini A · Nutr Metab Cardiovasc Dis · 2026
  5. 05
    Blue light-activated berberine-gentamicin combination breaks down biofilms in diabetic foot ulcers
    Gonçalves ASC, Leitão MM, Simões M et al. · J Mater Chem B · 2026
  6. 06
    Berberine alleviates early brain injury after subarachnoid hemorrhage by inhibiting GSK3β-mediated CASP1-dependent pyroptosis
    Tan J, Zheng Z, Zeng Y et al. · Int Immunopharmacol · 2026
  7. 07
    Berberine Attenuates Intracranial Aneurysm Formation by Activating SIRT1 to Suppress HMGB1 Acetylation and NF-κB Signaling
    Tan J, Zeng Y, Zhu H et al. · Neurochem Res · 2026
  8. 08
    Berberine Reduces Atrial Lipotoxicity and Endoplasmic Reticulum Stress to Alleviate Heart Failure With Preserved Ejection Fraction (HFpEF)-Associated Atrial Fibrillation via AMPK Signaling
    Cao Z, Duan J, Meng S et al. · Phytother Res · 2026
  9. 09
    Tianhuang formula attenuates cardiomyocyte pyroptosis in myocardial infarction by suppressing oxidative stress and the cGAS-STING-NLRP3 axis
    Yan M, Chen Y, Cai G et al. · Front Immunol · 2026
  10. 10
    EMP1-driven ferroptosis in liver sinusoidal endothelial cells exacerbates hepatic ischemia-reperfusion injury via P38 MAPK
    Yang Z, Wang Z, Huang J et al. · Free Radic Biol Med · 2026
  11. 11
    Mechanisms and applications of natural plant ingredients in modulating amino acid metabolism for the improvement of diabetic retinopathy: a review
    Zhang LY, Zhang TY, Zheng YJ et al. · Front Endocrinol (Lausanne) · 2026
  12. 12
    The Effect of Some Complementary Medicine Active Components on Rat Embryonic Heart Rate In Vitro
    Ritchie HE, Xia A, Polson JW · Birth Defects Res · 2026
  13. 13
    Role of Qrich1-mediated endoplasmic reticulum stress pathway in Berberine inhibition of NF-κB activation induced by cerebral ischemia-reperfusion injury
    Li J, Zhu Y, Han J et al. · J Stroke Cerebrovasc Dis · 2026
  14. 14
    Dingxin recipe III ameliorates endothelial cell senescence in atherosclerosis by activating the FOXO3a/PINK1/Parkin axis
    Liu X, Jin Y, Li Z et al. · J Ethnopharmacol · 2026
  15. 15
    Integrative Network Pharmacology and Molecular Docking-Based Validation of Berberine as a Therapeutic Agent in Arsenic-Induced Cardiotoxicity
    Krishnamoorthy S, Veeraraghavan VP, Renu K · Cardiovasc Toxicol · 2026
  16. 16
    Berberine inhibits NLRP3 inflammasome activation by upregulating the SIRT6-AMPK pathway to prevent angiotensin II-induced fibrosis and vulnerability to atrial fibrillation
    Zhou Z, Xu Y, Xiao X et al. · Int Immunopharmacol · 2026
  17. 17
    Clinical Efficacy of Curcumin, Resveratrol, Silymarin, and Berberine on Cardio-Metabolic Risk Factors Among Patients With Type 2 Diabetes Mellitus: A Systemic Review and Bayesian Network Meta-Analysis
    Miao R, Zhang B, Zhou D et al. · Phytother Res · 2025SR
  18. 18
    Intraplaque neovascularization and progression of atherosclerosis: A review of SMI technical assessment and berberine-statin regulatory mechanisms
    Sun X, Wang F · Medicine (Baltimore) · 2025
  19. 19
    Berberine ameliorates atherosclerosis by inhibiting the phenotypic transition of vascular smooth muscle cells via suppression of the JAK2/STAT3 signaling pathway
    Zheng J, Wang T, Zhou Y et al. · Eur J Pharmacol · 2025
  20. 20
    Cardiovascular toxicity associated with supplement use
    Corcoran J · Clin Toxicol (Phila) · 2025
  21. 21
    Animal studies and AI-based analysis identify the efficacy of berberine to inhibit experimental abdominal aortic aneurysms
    Tian K, Tian R, Qin L et al. · Phytomedicine · 2025
  22. 22
    Landscape of Berberine Targets: A Potential Pharmacological Insight for Heart Failure Treatment
    Wen S, Liu X, Liu L et al. · J Cardiovasc Pharmacol · 2025
  23. 23
    Berberine Attenuates Pyroptosis in Renal Tubular Epithelial Cells by Activating the FOXO3a/ARC Pathway
    Wang X, Huang F · J Appl Toxicol · 2025
  24. 24
    Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks
    Dobre MZ, Virgolici B, Doicin IC et al. · Int J Mol Sci · 2025
  25. 25
    Sirtuins regulate macrophage polarization in heart failure: Metabolic reprogramming, epigenetic regulation, and immune cell interactions
    Lin R, Zhu Y, Liu Y et al. · Pharmacol Res · 2025

Longevity & aging · 51

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  1. 01
    A Novel Mechanism of Berberine Targeting EIF2AK2 Dimerization Attenuates Methylglyoxal-Induced Endothelial Senescence and Apoptosis
    Chen J, Yang Y, Li H et al. · Phytother Res · 2026
  2. 02
    Natural senotherapeutics in respiratory health: Addressing cellular senescence, inflammaging, and immunosenescence in the aging lung
    Juan ME, Verdaguer E, Prohens R et al. · Eur J Pharmacol · 2026
  3. 03
    FOXO: a key target in regulating aging and age-related diseases
    Wang W, Zhu H, Jiang Q et al. · Biogerontology · 2026
  4. 04
    Dingxin recipe III ameliorates endothelial cell senescence in atherosclerosis by activating the FOXO3a/PINK1/Parkin axis
    Liu X, Jin Y, Li Z et al. · J Ethnopharmacol · 2026
  5. 05
    Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically diverse Caenorhabditis nematodes
    Banse SA, Sedore CA, Coleman-Hulbert A et al. · Elife · 2025
  6. 06
    M6PR upregulation by berberine attenuates hepatic senescence via sorting STING into endosome for degradation
    Tang W, Zhang Q, Qin L et al. · Phytomedicine · 2025
  7. 07
    Berberine Ameliorates Postoperative Cognitive Dysfunction in Aged Mice and Regulates the PI3K-AKT Pathway: A Network Pharmacology Study
    Li X, Meng S, Liu J et al. · J Cell Mol Med · 2025
  8. 08
    Berberine Derivative B68 Promotes Tumor Immune Clearance by Dual-Targeting BMI1 for Senescence Induction and CSN5 for PD-L1 Degradation
    Hu H, Wang Q, Yu D et al. · Adv Sci (Weinh) · 2025
  9. 09
    Berberine Inhibited SASP-Related Inflammation through RXRα/PPARγ/NEDD4 Pathway in Atherosclerosis
    Zheng Y, Kou J, Gao X et al. · Am J Chin Med · 2025
  10. 10
    Berberine extends healthspan and delays neurodegenerative diseases in Caenorhabditis elegans through ROS-dependent PMK-1/SKN-1 activation
    Xiao Y, Zhang L, Zhou H et al. · Arch Gerontol Geriatr · 2025
  11. 11
    Berberine promotes primordial follicle activation and increases ovulated oocyte quantity in aged mice
    Liu S, Wang W, Liu H et al. · Mol Med · 2024
  12. 12
    Berberine attenuates brain aging via stabilizing redox homeostasis and inflammation in an accelerated senescence model of Wistar rats
    Yadawa AK, Srivastava P, Singh A et al. · Metab Brain Dis · 2024
  13. 13
    Network pharmacology, molecular docking, and molecular dynamics simulation to elucidate the mechanism of anti-aging action of Tinospora cordifolia
    Bisht A, Tewari D, Kumar S et al. · Mol Divers · 2024
  14. 14
    Berberine: Pharmacological Features in Health, Disease and Aging
    Gasmi A, Asghar F, Zafar S et al. · Curr Med Chem · 2024
  15. 15
    Tetrahydroberberrubine retards heart aging in mice by promoting PHB2-mediated mitophagy
    Wang L, Tang XQ, Shi Y et al. · Acta Pharmacol Sin · 2023
  16. 16
    Senescent Phenotype of Astrocytes Leads to Activation of BV2 Microglia and N2a Neuronal Cells Death
    Zhang W, Yang X, Liu J et al. · Molecules · 2022
  17. 17
    Berberine-mediated REDD1 down-regulation ameliorates senescence of retinal pigment epithelium by interrupting the ROS-DDR positive feedback loop
    Chen Q, Xin G, Li S et al. · Phytomedicine · 2022
  18. 18
    Exploring the role of senescence inducers and senotherapeutics as targets for anticancer natural products
    Mamun AA, Sufian MA, Uddin MS et al. · Eur J Pharmacol · 2022
  19. 19
    Berberine exerts protective effects on cardiac senescence by regulating the Klotho/SIRT1 signaling pathway
    Li C, Jiang S, Wang H et al. · Biomed Pharmacother · 2022
  20. 20
    Molecular mechanisms of exceptional lifespan increase of Drosophila melanogaster with different genotypes after combinations of pro-longevity interventions
    Shaposhnikov MV, Guvatova ZG, Zemskaya NV et al. · Commun Biol · 2022
  21. 21
    Ferulic acid and berberine, via Sirt1 and AMPK, may act as cell cleansing promoters of healthy longevity
    DiNicolantonio JJ, McCarty MF, Assanga SI et al. · Open Heart · 2022
  22. 22
    Pterocarpus marsupium extract extends replicative lifespan in budding yeast
    Lee MB, Kiflezghi MG, Tsuchiya M et al. · Geroscience · 2021
  23. 23
    Berberine, a natural alkaloid sensitizes human hepatocarcinoma to ionizing radiation by blocking autophagy and cell cycle arrest resulting in senescence
    Ramesh G, Das S, Bola Sadashiva SR · J Pharm Pharmacol · 2020
  24. 24
    Berberine ameliorates renal injury in a rat model of D-galactose-induced aging through a PTEN/Akt-dependent mechanism
    El-Horany HE, Gaballah HH, Helal DS · Arch Physiol Biochem · 2020
  25. 25
    Inhibitor of Differentiation 1 (Id1) in Cancer and Cancer Therapy
    Zhao Z, Bo Z, Gong W et al. · Int J Med Sci · 2020